Concepedia

Induction of interferon synthesis in mice by fractions from Nocardia

R. Barot-Ciorbaru, J Wietzerbin, J.F. Petit, L Chedid, E Falcoff, E. Lederer

Infection and Immunity · 1978 · 28 citations · 11 references

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Concepts

Abstract

Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.

References

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Production of High-Titered Interferon in Cultures of Human Diploid Cells

Edward A. Havell, J Vilček · Antimicrobial Agents and Chemotherapy · 1972 · 472 citations · Full text

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Production and Properties of Migration Inhibitory Factor and Interferon in the Circulation of Mice with Delayed Hypersensitivity

Julius S. Youngner, S. B. Salvin · The Journal of Immunology · 1973 · 307 citations

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Interferon Appearance Stimulated by Endotoxin, Bacteria, or Viruses in Mice Pre-Treated with Escherichia coli Endotoxin or Infected with Mycobacterium tuberculosis

Julius S. Youngner, Warren R. Stinebring · Nature · 1965 · 141 citations

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Purification of Mouse Interferon by Affinity Chromatography on Anti-Interferon Globulin-Sepharose

Clifton A. Ogburn, Kurt Berg, Kurt Paucker · The Journal of Immunology · 1973 · 118 citations · Full text

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Isolation of mitogenic and adjuvant active fractions from various species of Nocardiae

R Ciorbaru, A. Adam, J.F. Petit et al. · Infection and Immunity · 1975 · 73 citations · Full text

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