A<i>cis</i>Amide Bond Surrogate Incorporating 1,2,4-Triazole

Abstract

A novel cis amide bond surrogate incorporating 1,2,4-triazole was designed and synthesized by the reaction of a thionotripeptide, formic hydrazide, and mercury(II) acetate. This method of surrogate formation was also applicable to a cyclic thionopeptide.