Concepedia

Spirooxadiazoline oxindoles with promising <i>in vitro</i> antitumor activities

Carlos J. A. Ribeiro, Joana D. Amaral, Cecília M. P. Rodrigues, Rui Moreira, Maria M. M. Santos

MedChemComm · 2015 · 32 citations · 22 references

DOI

Concepts

Abstract

This paper reports the synthesis and biological evaluation of thirty one spirooxadiazoline oxindoles as potential anticancer agents.

References

22

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Qingjie Ding, Zhuming Zhang, Jinjun Liu et al. · Journal of Medicinal Chemistry · 2013 · 597 citations · Full text

, , +11

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

Marc Germain, El Bachir Affar, Damien D’Amours et al. · Journal of Biological Chemistry · 1999 · 451 citations · Full text

, , +16

Recent advances in the synthesis of biologically active spirooxindoles

Maria M. M. Santos · Tetrahedron · 2014 · 395 citations

, , +13

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

Binh Thanh Vu, Peter M. Wovkulich, Giacomo Pizzolato et al. · ACS Medicinal Chemistry Letters · 2013 · 382 citations · Full text

, , +14