<i>Tpmt</i> Gene Expression is Increased During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia Patients in a <i>TPMT</i> Gene Promoter Variable Number of Tandem Repeat-Dependent Manner

Abstract

The TPMT promoter genetic variants need to be considered at the very beginning of the maintenance therapy for childhood ALL patients. The TPMT promoter VNTR region may serve as a pharmacogenomic biomarker when introducing thiopurine therapy.