MedicinePharmacologyPharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyPreventive CardiologyCardiovascular DiseaseCardiovascular Disease PreventionCardiovascular PharmacologyCardiovascular Risk ReductionHypertension PreventionLipid-lowering TherapyBlood PressureCardiovascular Disease ManagementCardiovascular Risk MarkersCholesterol Lowering PreventionLipid-lowering Drug EfficacyLow-density Lipoprotein Cholesterol LoweringLow-density Lipoprotein Cholesterol ReductionSecondary Prevention Of Dyslipidemia
The objective of this article is to determine the combination of drugs and vitamins, and their doses, for use in a single daily pill to achieve a large effect in preventing cardiovascular disease with minimal adverse effects. The strategy was to simultaneously reduce four cardiovascular risk factors (low density lipoprotein cholesterol, blood pressure, serum homocysteine, and platelet function) regardless of pretreatment levels.