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Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design

Medicinal ChemistryBiochemistryAnti-trypanosoma Cruzi AgentsRational DesignNatural SciencesMedicineAntiparasitic AgentAfrican TrypanosomiasisAnti-cancer AgentDrug DevelopmentChemical BiologyPharmacologyDrug DiscoveryTrypanothione Reductase