MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative ¹⁷⁷Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy

TLDR

Accurate absorbed dose calculations in personalized radionuclide therapy depend on precise activity estimates at each imaging time point, and MIRD 23 provides a general overview of quantitative SPECT methods. The paper focuses on 177Lu and its use in radiopharmaceutical therapy. This document supplies isotope‑specific guidelines for 177Lu, extending the general recommendations of MIRD 23. MIRD Pamphlet No.

Abstract

The accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the accuracy of the activity (or activity concentration) estimates obtained at each of the imaging time points. MIRD Pamphlet no. 23 presented a general overview of methods that are required for quantitative SPECT imaging. The present document is next in a series of isotope-specific guidelines and recommendations that follow the general information that was provided in MIRD 23. This paper focuses on ¹⁷⁷Lu (lutetium) and its application in radiopharmaceutical therapy.