Concepedia

Design and synthesis of potent N1-substituted indole melatonin receptor agonists.

Andrew Tsotinis, Andreas Eleutheriades, Katherine Hough, David Sugden

PubMed · 2003 · 13 citations · 12 references

Concepts

Abstract

The design and expeditious synthesis of two new indole analogs with up to 5-fold potency of that of melatonin is described.

References

12

Mapping the Melatonin Receptor. 6. Melatonin Agonists and Antagonists Derived from 6<i>H</i>-Isoindolo[2,1-<i>a</i>]indoles, 5,6-Dihydroindolo[2,1-<i>a</i>]isoquinolines, and 6,7-Dihydro-5<i>H</i>-benzo[<i>c</i>]azepino[2,1-<i>a</i>]indoles

Rüdiger Faust, Peter J. Garratt, Robert J. Jones et al. · Journal of Medicinal Chemistry · 2000 · 184 citations · Full text

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Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin

Samuel Cos, J. Recio, Emilio J. Sánchez‐Barceló · Life Sciences · 1996 · 82 citations

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Conformationally Restrained Melatonin Analogues:  Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study

Gilberto Spadoni, Cesarino Balsamini, Giuseppe Diamantini et al. · Journal of Medicinal Chemistry · 1997 · 75 citations · Full text

, , +17

Mapping the Melatonin Receptor. 4. Comparison of the Binding Affinities of a Series of Substituted Phenylalkyl Amides

Peter J. Garratt, Sylvie Travard, Stefan Vonhoff et al. · Journal of Medicinal Chemistry · 1996 · 72 citations · Full text

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Melatonin Receptor Ligands:  Synthesis of New Melatonin Derivatives and Comprehensive Comparative Molecular Field Analysis (CoMFA) Study

Marco Mor, Silvia Rivara, Cláudia Gontijo Silva et al. · Journal of Medicinal Chemistry · 1998 · 69 citations · Full text

, , +17