Concepedia

Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe

Lekshmi R. Nath, Jaggaiah N. Gorantla, Sophia Margaret Joseph, Jayesh Antony, Sanu Thankachan, Darsan B Menon, Ravi S. Lankalapalli, Ruby John Anto

RSC Advances · 2015 · 86 citations · 29 references

DOI

Concepts

Abstract

We report the isolation and characterization of four compounds from a cytotoxic fraction F-17, isolated from the DCM extract of<italic>C. odorata</italic>by bioactivity guided fractionation.

References

29

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Scott H. Kaufmann, Serge Desnoyers, Yvonne Ottaviano et al. · PubMed · 1993 · 1.9K citations

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Worldwide burden of cervical cancer in 2008

Marc Arbyn, Xavier Castellsagué, Silvia de Sanjosé et al. · Annals of Oncology · 2011 · 1.1K citations

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Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells

Suby Oommen, Ruby John Anto, Gopal Srinivas et al. · European Journal of Pharmacology · 2003 · 235 citations

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Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

Toan‐Thang Phan, Lingzhi Wang, Patrick See et al. · Biological and Pharmaceutical Bulletin · 2001 · 228 citations · Full text

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Sensitization of Taxol-induced Apoptosis by Curcumin Involves Down-regulation of Nuclear Factor-κB and the Serine/Threonine Kinase Akt and Is Independent of Tubulin Polymerization

Smitha V. Bava, Vineshkumar T. Puliappadamba, Ayswaria Deepti et al. · Journal of Biological Chemistry · 2004 · 226 citations · Full text

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