Synthesis and Antihypertensive α-Blocking Activity Evaluation of Thiazole Derivatives Bearing Pyrazole Moiety

Abstract

A novel, facile reaction for the synthesis of series of thiazole derivatives has been developed from the reaction of the appropriate thiosemicarbazone derivatives and 2-bromo-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone in ethanol under reflux.The structures of the newly synthesized products were established on the basis of spectral data (mass, IR, 1 H and 13 C NMR) and elemental analyses.The pharmacological screening showed that many of the synthesized compounds exhibit a good antihypertensive α-blocking activity and having low toxicity, as compared to Minoxidil.