Synthesis of Some Novel 6‐Benzyl(or Substituted Benzyl)‐2‐β‐<scp>d</scp>‐Glucopyranosyl‐1,2,4‐Triazolo[4,3‐<i>b</i>][1,2,4]Triazines as Potential Antimicrobial Chemotherapeutics

Abstract

Glucosidation of the new 8-amino-6-benzyl(or substituted benzyl)-2,8-dihydro-1,2,4-triazolo[4,3-b][1,2,4]triazin-7(3H)-ones (3a-d) with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide 4 gave the corresponding N-glucosides 5a-d. Chemical transformations leading to new functionalities have also been achieved to give compounds 7-12. Antimicrobial activity of compounds 5a-c against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli is described.