<i>Variations of Serum Carbonic Acid pk' With ph and Temperature</i>

Abstract

Human and canine serum carbonic acid pk' was shown to vary inversely with ph as well as with temperature. At ph 7.4 and 37.5°C the accepted value should be lowered from 6.10 to 6.09. The rise in pk' for a 1.0 unit fall in ph was 0.044 at 37.5° and 0.063 at 24°. The rise in pk' for a 1°C fall in temperature was 0.0054 at ph 7.4 and 0.0063 at ph 6.8. A nomogram was constructed to define pk' for temperatures from 10° to 45°C, and for ph values from 6.6 to 8.0. Submitted on February 8, 1956