<b>DEGENERATIVE CHANGES IN THE CENTRAL NERVOUS SYSTEM OF JAPANESE MONKEYS INDUCED BY ORAL ADMINISTRATION OF ALUMINUM </b><b>SALT </b>

Abstract

Experimental studies on aluminum (Al) neurotoxicity were conducted using 16 adult male Japanese monkeys (Macacafuscata) under a Ca,Mg-deficient condition. The Ca,Mg-deficiency is one of the known factors in the high incidence of amy0trophic lateral sclerosis (ALS) in the Kii Peninsula (Japan), Guam Island, and West New Guinea (Western Pacific areas). In Al neurotoxicity induced by Ca,Mg-def1ciency and excess Al, were observed body weight loss, increase in plasma creatine phosphokinase activity, muscle atrophy, chromatolytic spinal neurons with eccentric nuclei, increase in number of argyrophilic bodies, and accumulation of mal-