American Journal of Clinical Pathology · 2015 · 10 citations · 16 references
MedicineOncologyPathologyNeoplasiaSurgical OncologyTumor HeterogeneityDuctal Carcinoma In SituMalignant NeoplasmsMalignant TumorsTumor CharacterizationTumor ClassificationTumor MorphologyDifferential Diagnosis CriteriaDuctal Carcinoma CytologyGross Differential DiagnosisLobular Carcinoma CytologyLobular Carcinoma In SituM CellsMultinucleation DetectionTumor Cell Morphology
OBJECTIVES: Bi- and multinucleated (B/M) cells are present in a variety of tumors. We evaluated lobular carcinoma in situ (classic and pleomorphic types) and ductal carcinoma in situ (DCIS) to determine if this objective morphologic feature aids the differential diagnosis. METHODS: The number of B/M cells was recorded in pleomorphic lobular carcinoma in situ (PLCIS) (n = 20), classic lobular carcinoma in situ (CLCIS) (n = 26), and DCIS (n = 37). RESULTS: Binucleated cells were significantly more frequent in PLCIS (100%) vs DCIS (43%; P < .0001) and CLCIS (54%; P = .0004). Multinucleated cells were present in 25% of PLCIS cases and 8% of DCIS cases, and they were absent in CLCIS. The quantity of B/M per high-power field (hpf) was less in DCIS (mean, 1.1) and CLCIS (mean, 2.5) compared with PLCIS (mean, 5.8). Thirty-five percent of PLCIS cases had more than five B/M per hpf. CONCLUSIONS: Binucleated cells are significantly more frequent in PLCIS vs CLCIS and DCIS. Multinucleated cells were never identified in CLCIS. PLCIS should be considered as a diagnosis when B/M is noted.
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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion
Michael Overholtzer, Arnaud Mailleux, Ghassan Mouneimne et al. · Cell · 2007 · 738 citations · Full text
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.
R Moll, M. Mitze, U H Frixen et al. · PubMed · 1993 · 462 citations