Tye Aqueous Solubility of Variously Substituted Barbituric Acids. I. Chemical Effects

Abstract

The aqueous solubility of fourteen variously substituted barbituric acid was determined at 25°C. There was an approximate relationship between aqueous solubility and the duration of activity. The magnitudes of solubility varied substantially for these compounds and these results are based upon the net chemical grouping effect from compound to compound. While several compounds possessed rather similar melting points, the solubilities also varied to a large extent. These results are discussed further in this communication.