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Skin antisepsis with chlorhexidine–alcohol versus povidone iodine–alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial

AntibioticsAntimicrobial StewardshipHealthcare-associated InfectionSkin ScrubbingTwo-by-two Factorial TrialDermatologyInfection ControlSkin AntisepsisMedicineAntimicrobial Resistance