Association of Impaired Left Ventricular Twisting-Untwisting with Vascular Dysfunction, Neurohumoral Activation and Impaired Exercise Capacity in Hypertensive Heart Disease

Abstract

Impaired LV untwisting is associated with increased arterial stiffness and coronary microcirculatory dysfunction, and is linked to reduced exercise capacity and neurohumoral activation in hypertensive heart disease. A fibrotic process may be the common link between vascular dysfunction and abnormal myocardial deformation.