Indian Journal of Pharmaceutical Sciences · 2001 · 13 citations · 0 references
Life SciencesBotanyPlant SciencesHepatotoxicologyPlant BiochemistryPlant PhysiologyHepatic MetabolismHepatic ToxicityLiver DiseaseMedicinal PlantsOxidative Stress In HepatotoxicityAntioxidant Protection Against HepatotoxicityCarbon Tetrachloride HepatotoxicityCarbon Tetrachloride ToxicityHepatocellular Liver InjuryHistopathological EffectsPlant Extract AntioxidantsSerum Total ProteinTotal Serum Bilirubin
The plant Cassia angustifolia vahl has been used in various diseases. The alcoholic extract of the plant was investigated for the hepatoprotective properties against carbon tetrachloride-induced liver damage. Various biochemical parameters were studied to evaluate the hepatoprotective activity of crude extract. In serum, total bilirubin, total protein, glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) were determined. In addition to these glutathione (GSH) and lipid peroxides (LPO) were determined in liver tissue and is supported by histopathological studies of liver before and after the treatment. Results of this study revealed that leaves of Cassia angustifolia could afford a significant protective action in CCl4-induced hepatocellular injury.