IL-6 plays an obligatory role in late preconditioning via JAK?STAT signaling and upregulation of iNOS and COX-2

Abstract

IL-6 does not modulate myocardial infarct size in naïve myocardium. However, following a PC stimulus, IL-6 is obligatorily required for the activation of the JAK-STAT pathway, the ensuing upregulation of iNOS and COX-2 (co-mediators of late PC), and the development of a cardioprotective phenotype.