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Inhibition of human thymidine phosphorylase by conformationally constrained pyrimidine nucleoside phosphonic acids and their “open-structure” isosteres

Nucleic Acid ChemistryPhosphonic AcidsBiochemistryNatural SciencesHuman Thymidine PhosphorylaseNucleic Acid BiochemistryMolecular BiologyStructure-function Enzyme KineticsProtein Phosphorylation