Solid‐Phase Methodology for Synthesis of <i>O</i>‐Alkylated Aromatic Oligoamide Inhibitors of α‐Helix‐Mediated Protein–Protein Interactions

Abstract

Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).