Contribution of CYP3A5 to the in Vitro Hepatic Clearance of Tacrolimus

Abstract

CYP3A5 affects metabolism of tacrolimus, thus explaining the association between CYP3A5 genotype and tacrolimus dosage. The importance of CYP3A5 status for tacrolimus clearance is also dependent on the concomitant CYP3A4 activity.