Concepedia

Amphotericin B Formulations Exert Additive Antifungal Activity in Combination with Pulmonary Alveolar Macrophages and Polymorphonuclear Leukocytes against <i>Aspergillus fumigatus</i>

Emmanuel Roilides, Caron A. Lyman, Joanna Filioti, Onome Akpogheneta, Tin Sein, C. G. Lamaignere, Rūta Petraitienė, Thomas J. Walsh

Antimicrobial Agents and Chemotherapy · 2002 · 51 citations · 25 references

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Abstract

Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

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