Epidural Bupivacaine/Sufentanil Therapy for Postoperative Pain Control in Patients Tolerant to Opioid and Unresponsive to Epidural Bupivacaine/Morphine

Abstract

These results suggest that sufentanil can be used successfully in opioid-tolerant patients who do not experience adequate pain control in the early postoperative period despite a large dose of epidural morphine. Moreover, sufentanil should be considered an effective alternative therapy for postoperative pain control in chronic opioid users using high doses of oral opioids before surgical intervention.