Palladium‐Based Nanocatalyst for One‐Pot Synthesis of Polysubstituted Quinolines

Abstract

Abstract The synthesis of quinolines has been achieved through a one‐pot, two‐step tandem reaction catalyzed with AgPd alloy nanoparticles supported on carbon. AgPd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α‐alkylated ketones under an Ar flow. These are reacted with 2‐aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.