Adipose Depletion and Apoptosis Induced by Trans‐10, Cis‐12 Conjugated Linoleic Acid in Mice*

Abstract

CLA10,12, but not CLA9,11, can induce both body fat loss and adipose apoptosis. Although mice of a genotype with less body fat and greater metabolic rate and feed intake appear less sensitive, these CLA effects are robust for mice of varying metabolic background.