Using a Core–Sheath Distribution of Surface Chemistry through 3D Tissue Engineering Scaffolds to Control Cell Ingress

Abstract

A core/sheath distribution of cell-adhesive and non-cell-adhesive surface coatings is produced in porous biodegradable poly(D,L-lactic acid) discs using sequential plasma polymerization. The figure and cover show an X-ray micro-computed tomography image of a section of a 10 mm diameter, 4 mm thick scaffold where fibroblast cells (shown in red) have been encouraged by the surface chemistry to penetrate to the scaffold core. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c2719_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.