Exogenous alpha-1-Acid Glycoprotein Protects against Renal Ischemia-Reperfusion Injury by Inhibition of Inflammation and Apoptosis

Abstract

Both natural and fucose-depleted hAGP protect against renal I/R injury by preservation of tubular epithelial structure and inhibition of apoptosis and subsequent inflammation. Therefore, hAGP can be regarded as a potential new therapeutic intervention in the treatment of acute renal failure, as seen after transplantation of ischemically injured kidneys.