Selective Inhibition of c‐Myc/Max Dimerization by a Pyrazolo[1,5‐<i>a</i>]pyrimidine

Abstract

c-Myc/Max Dimerization. The interaction between the oncoprotein c-Myc and its activation partner Max is considered to be a desirable target for cancer drug development. However, the interaction is mediated by large α-helical interfaces without obvious binding sites for small molecule inhibitors. This paper describes the identification of a substitution pattern for pyrazolopyrimidines which appears to be associated with activity against this challenging target. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2007/z600294_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.