Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB

Abstract

The first virtual screening search through the entire chemical space of small organic ligands has identified promising ligands as inhibitors of the N-methyl-D-aspartic acid (NMDA) receptor glycine site. This receptor is an important drug target implicated in synaptic plasticity, neuronal development, learning, and memory. Inhibiting the NMDA receptor may help prevent neuronal cell death caused by glutamate excitotoxicity in acute and chronic neurodegenerative disorders. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2008/z800198_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.