In Vitro Interactions of Micafungin with Other Antifungal Drugs against Clinical Isolates of Four Species of <i>Cryptococcus</i>

Abstract

The combination of micafungin (MFG) with amphotericin B (AMB), fluconazole, itraconazole, voriconazole, or ravuconazole was evaluated against 37 strains of four species of Cryptococcus by the checkerboard method. Antagonism was never seen. Synergy was observed for some isolates for each combination and was most frequent with MFG-AMB.