Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts <i>in vitro</i>

Abstract

These results support the theory that BP-ONJ is a multifactorially caused disease because several cell lines of the oral cavity which are responsible for integrity and wound healing are negatively affected by nitrogen-containing bisphosphonates. Perioperative interruption of bisphosphonate application during dental surgical procedures--if possible--might be feasible to promote better wound healing.