Nuclear to cytoplasmic compartment shift of the p33^<i>ING1b</i> tumour suppressor protein is associated with malignancy in melanocytic lesions

Abstract

Cytoplasmic immunostaining for p33ING1b using MAb GN2 is strongly associated with 'activated' melanocytic lesions; therefore it is possible that this MAb could be of value in diagnostic practice. Furthermore, the reduction in p33ING1b expression and perhaps translocation from the nucleus to the cytoplasm may play a central role in the development and progression of melanomas.