The Journal of Infectious Diseases · 2011 · 111 citations · 14 references
Veterinary MedicineInfectious DiseasesPreventive MedicineDisease PreventionEpidemiologyInfectious Disease EpidemiologyCluster DetectionDisease SpreadHiv EpidemiologyPrevention Of Sexual TransmissionTransmission DynamicsTransmission Network AnalysisEpidemiologic Data AnalysisHeterogeneity In Disease SpreadHiv Cluster AnalysisHiv Population DynamicsHiv Spatial DistributionHiv Transmission DynamicsProspective Cohort DataSexual Network Analysis
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (χ(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.
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Bayesian Phylogeography Finds Its Roots
Philippe Lemey, Andrew Rambaut, Alexei J. Drummond et al. · PLoS Computational Biology · 2009 · 1.9K citations · Full text
Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics
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