Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12☆

Abstract

Acidosis, rather than anoxia, is an important trigger of apoptosis in EC under simulated ischemia. The main pathway of the simulated ischemia-induced apoptosis consists of the Ca2+ leak from the ER followed by activation of caspase-12 and caspase-3.