Different amplifying mechanisms of interleukin‐17 and interferon‐γ in Fcγ receptor–mediated cartilage destruction in murine immune complex–mediated arthritis

Abstract

Our findings indicate that IL-17-mediated aggravation of cartilage destruction in IC-mediated arthritis is FcgammaR dependent. However, in contrast to IFNgamma, which directly up-regulates FcgammaR expression on macrophages and PMNs, IL-17 enhances cartilage destruction by increasing the local amount of FcgammaR-bearing neutrophils.