Analysis of the <i>RET</i> , <i>GDNF</i> , <i>EDN3</i> , and <i>EDNRB</i> genes in patients with intestinal neuronal dysplasia and Hirschsprung disease

Abstract

The mutation frequency found in our sporadic HSCR patients (10%) and the allelic distribution of RET polymorphisms are comparable with earlier published data. A significantly different allelic distribution in an established HSCR associated polymorphism argues against common genetic pathways for HSCR and IND.