Differential Cytotoxicity and Particle Action of Hydroxyapatite Nanoparticles in Human Cancer Cells

Abstract

Varying cytotoxicity of HAPNs was observed in different cancer cell types. Our results suggest that possible mechanisms of cytotoxicity in various types of cancer cells could be different. The elevated calcium concentration and nuclear localization of the particles might be the main mechanism of growth inhibition by HAPNs in cancer cells.