Novel 3- <i>N</i> -Aminoglycoside Acetyltransferase Gene, <i>aac</i> ( <i>3</i> )- <i>Ic</i> , from a <i>Pseudomonas aeruginosa</i> Integron

Abstract

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.