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Highly Enantioselective Cyclopropanation with Co(II)-Salen Complexes: Control ofcis- andtrans-Selectivity by Rational Ligand-Design
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2001
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Rational Ligand-designDerivativesComplex 6EngineeringEnantioselective CyclopropanationCoordination ComplexOrganic ChemistryOrganometallic CatalysisMolecular ComplexStyrene DerivativesChemistryComplex 14Asymmetric CatalysisControl Ofcis- Andtrans-selectivityEnantioselective SynthesisBiomolecular Engineering
Cyclopropanation of styrene derivatives with alkyl α-diazoacetate in the presence of the second-generation (salen)cobalt(II) complex 6 proceeded with excellent cis- and enantioselectivity. On the other hand, the cyclopropanation in the presence of complex 14 which was designed on the basis of the mechanism of asymmetric induction by complex 6 showed good trans- and excellent enantioselectivity.