Regioselective access to CF₃S-substituted dihydrofurans from homopropargylic alcohols with trifluoromethanesulfenamide

Abstract

A facile access to 4-((trifluoromethyl)thio)-2,3-dihydrofurans from unprotected homopropargylic alcohols in high regioselectivity is reported. This method is the first example of using a free hydroxy group as a nucleophile to complete a trifluoromethylthiolation/cyclization protocol with an alkyne in moderate to excellent yields.