Gold(I)‐Catalyzed One‐Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo‐/Pyrido[2,1‐<i>b</i>]benzo[<i>d</i>][1,3]oxazin‐ 1‐ones

Abstract

Abstract A highly efficient method has been developed for the one‐pot synthesis of multi‐ring heterocyclic compounds such as pyrrolo‐/pyrido[2,1‐ b ]benzo[ d ][1,3]oxazin‐1‐ones from o ‐aminobenzyl alcohols via a gold(I)‐catalyzed tandem coupling/cyclization reaction. Significantly, the strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic molecular architectures in which two new CN bonds and one CO bond are formed in a one‐pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.