The Effect of Paroxetine on 5-HT_2A Receptors in Depression: An [¹⁸F]Setoperone PET Imaging Study

Abstract

5-HT(2A) receptors down-regulate in young depressed subjects after treatment with paroxetine, but this down-regulation attenuates with age. This suggests that over 6 weeks paroxetine treatment increases 5-HT agonism on 5-HT(2A) receptors in the cortex of young patients with depression.