Journal of Clinical Microbiology · 1989 · 408 citations · 2 references
Life SciencesInfectious DiseasesMicrobiologyMedical MicrobiologyMicrobial PhysiologyMucosal ImmunologyBacterial ToxinsGastric DiseasesGastric DisordersGastrointestinal InfectionsGastrointestinal InflammationPeptic Ulcer DiseaseCytotoxin PathogenesisGastric Ulcer DiseaseHelicobacter Pylori InfectionHelicobacter Pylori PathogenesisPeptic Ulcer Disease PathophysiologyPeptic Ulcer Pathophysiology
A total of 66.6% of Campylobacter pylori strains isolated from patients with peptic ulcers produced a cytotoxin active against mammalian cells in vitro, versus 30.1% of strains isolated from patients with chronic gastritis of various degrees of severity only. This difference was statistically significant and suggests that the toxic substance could be involved in the development of peptic ulcers.
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Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
R D Leunk, P T Johnson, Brien C. David et al. · Journal of Medical Microbiology · 1988 · 681 citations