Structure of pyridindolol, inhibitor of .BETA.-galactosidase.

Abstract

Pyridindolol is a product of a streptomyces and exhibits inhibitory activity against bovine liver β-galactosidase. The structure of pyridindolol, 1-[1(R), 2-dihydroxyethyl]- 3-hydroxymethyl-9H-pyrido[3, 4-b] indole, has been established by spectroscopic analyses and an X-ray structure determination. Pyridindolol (I) inhibits bovine liver β-galactosidase in acidic conditions and its production, isolation and properties were reported in a previous paper1). This paper is concerned with the structure determination of the new inhibitor.