Uric Acid Nephropathy: An Experimental Model

Abstract

SummaryA nephropathy was experimentally induced in rats by feeding a diet containing uric acid and oxonic acid, a uricase inhibitor. It was characterized by hyperuricemia, hyperuricosuria, deposition of uric acid in the kidney tubules, distention of tubular lumens, and early tubular and interstitial nephritis, and thus could serve as a useful experimental model for uric acid nephropathy.