Concepedia

Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer

Michael E. Mullendore, Jan-Bart Koorstra, Yue‐Ming Li, G. J. A. Offerhaus, Xing Fan, Clark M. Henderson, William Matsui, Charles G. Eberhart, Anirban Maitra, Georg Feldmann

Clinical Cancer Research · 2009 · 196 citations · 38 references

DOIFull text

Open access

Abstract

Our studies confirm that Notch activation is almost always ligand dependent in pancreatic cancer, and inhibition of Notch signaling is a promising therapeutic strategy in this malignancy.

References

38

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Siân Jones, D. Williams Parsons, Jimmy Lin et al. · Science · 2008 · 4K citations · Full text

, , +17

ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome

Christophe Ginestier, Min Hee Hur, Emmanuelle Charafe‐Jauffret et al. · Cell stem cell · 2007 · 4K citations · Full text

, , +9

Activating Mutations of <i>NOTCH1</i> in Human T Cell Acute Lymphoblastic Leukemia

Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee et al. · Science · 2004 · 2.7K citations

, , +13

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Sunil R. Hingorani, Emanuel F. Petricoin, Anirban Maitra et al. · Cancer Cell · 2003 · 2.5K citations · Full text

, , +8

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio et al. · Nature · 2005 · 1.5K citations · Full text

, , +10