Angewandte Chemie International Edition · 2012 · 242 citations · 57 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCatalyst DesignCatalyst SynthesisCatalytic MechanismsCatalytic Reaction KineticsHeterocycle SynthesisOrganic SynthesisC-h Bond ActivationCatalytic Cycle AnalysisCatalytic Cycle MechanismsCatalytic Reaction MechanismsKinetic Isotope Effects In Oxidative AdditionTransition Metal-catalyzed Synthesis
Directed, undirected! Rhodium(III)-catalyzed double CH bond activation (one directed, one undirected) provides an efficient route to biaryls (see scheme; DG=directing group). Significant kinetic isotope effects for both reaction partners and H/D scrambling between them are interesting experimental findings. While the mechanism is still unclear, a rhodium(V) species is invoked in the catalytic cycle.
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The Catalytic Cross-Coupling of Unactivated Arenes
David R. Stuart, Keith Fagnou · Science · 2007 · 1K citations