Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation

Oxidation of dihydropyridine calcium channel blockers and analogs by human liver cytochrome P-450 IIIA4

F. Peter Guengerich, William R. Brian, M. Iwasaki et al. · Journal of Medicinal Chemistry · 1991 · 263 citations

Medicine, Medicinal Chemistry, Pharmacology +16

The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily.

J. K. Faulkner, D. McGibney, LF Chasseaud et al. · British Journal of Clinical Pharmacology · 1986 · 225 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +15

The Metabolism and Pharmacokinetics of Amlodipine in Humans and Animals

D. A. Stopher, Alan Beresford, P. V. Macrae et al. · Journal of Cardiovascular Pharmacology · 1988 · 159 citations

Medicine, Pharmacokinetics, Pharmacology +9

Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers

Marshall J. Glesby, Judith A. Aberg, Michelle A. Kendall et al. · Clinical Pharmacology & Therapeutics · 2005 · 91 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs

Robert L. Walsky, R. Scott Obach, Ruth Hyland et al. · Drug Metabolism and Disposition · 2012 · 90 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17