Influence of dialdehyde bacterial cellulose with the nonlinear elasticity and topology structure of ECM on cell adhesion and proliferation

Abstract

Bacterial cellulose (BC) has attracted much attention as a novel biomaterial recently. In this work, the special chemical structure, topology structure and mechanical behavior of C2, 3-oxidized dialdehyde BC (DBC) were investigated. The DBC was prepared from the selective-oxidation of BC with sodium periodate. DBC membranes show obvious shrinkage in 2D direction with no significant changes in thickness. Similar to elastins, DBC exhibits a typical nonlinear elasticity, it can return to its original shape as soon as the deformation force is removed. Similarly to elastin, DBC exhibits a typical nonlinear elastic behavior. It can return to its original shape as soon as the deformation force is removed, and this nonlinear elastic behavior is typical for fiber networks in general. DBC has a nano-fiber network topology structure that is similar to the extracellular matrix. Moreover, the reaction between cell-surface proteins and aldehydes of DBC is conducive to the adhesion and proliferation of cells within the DBC networks. In general, the nonlinear elasticity, topology structure and cell adhesion of DBC were similar to the extracellular matrix. This demonstrates the potential of using DBC as a material in the repair process of injured tissues.